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As a layman, you can hardly really beat the ETFs in the long term (+15 years) with individual stocks.

Regarding your ETF selection: you need to know whether you want to invest in a US-only ETF.
I don't think it makes much sense to invest in the Nasdaq alongside the S&P500 because of the massive overlap.

But with the MSCI, you're taking the global economy with you, including a lot besides the US market.
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@Metis so would you split nasdaq resolution into everything in s&p and msci?
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@Kameltrader It just depends on your perception of risk. If it's worth it to you to take the risk and only bet on the 100 or so companies in the Nasdaq, then go for that. If you prefer to diversify across 500 companies, go for the S&P500.

But I would definitely go for the MSCI or similar global ETFs, especially if your investment horizon is at least 15/20/30 years.